After removal of the endothelium of the rabbit PCAs, L-arginine still relaxed rabbit PCAs. Carboxy-PTIO (nitric oxide scavenger) and L-NAME (nitric oxide synthase inhibitor) inhibited L-arginine-induced relaxation in rabbit PCAs. L-arginine relaxed high-K solution-induced contracted rabbit PCAs. Changes in optic disc blood flow were measured by laser speckle flowgraphy. Six volunteers received an intravenous drip infusion of 100Â ml of L-arginine or saline. After obtaining maximal contraction following administration of high-K solution, L-arginine was administrated. Vascular ring segments were mounted on a double myograph system. This study aimed to clarify the vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries (PCAs) and to investigate changes in optic disc blood flow after an infusion of L-arginine in vivo. Vasodilatory effect of L-arginine on isolated rabbit and human posterior ciliary arteries in vitro and increased optic disc blood flow in vivo.Ĭhuman, Hideki Sugimoto, Takako Nao-I, Nobuhisa
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